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Otsuka Podcast

The latest news from Otsuka's global team of professionals working to create new products for better health worldwide.
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Welcome to Otsuka Podcast, featuring stories of change from Otsuka Pharmaceutical's global team.

Please visit us at www.otsuka.co.jp for more stories and to see the photos and videos that accompany these episodes.

Apr 20, 2016

Read the original article with photos at:

https://www.otsuka.co.jp/en/company/globalnews/detail.php?id=227&date=2016-04-20

The Minister of Education, Culture, Sports, Science and Technology awarded Otsuka Pharmaceutical Co., Ltd. two commendations for Science and Technology in Tokyo, Japan.

One of the prizes for Science and Technology, in the Development Category, was for the research and development of delamanid. It is an effective treatment for multi-drug resistant tuberculosis. The other prize was for the development of tolvaptan, an antagonist of the vasopressin V2 receptor.

The commendations were presented in late spring in a ceremony held in the Ministry of Education, Culture, Sports, Science, and Technology.

Each year, 9.6 million people are newly infected by tuberculosis (TB). Of these cases, 480,000 patients develop multidrug-resistant tuberculosis (MDR-TB). And in that group, 22% develop extensively drug-resistant tuberculosis (XDR-TB). There have been no new anti-TB drugs developed since the introduction of rifampicin over forty years ago.

Senior director of the Pharmaceutical Business Division, Mr. Makoto Matsumoto, Ph.D., said, “Delamanid was approved as a new drug for the first time in approximately 40 years. However, many besides those being awarded this time contributed their efforts and cooperation during the approval process, which took over 20 years.”

He continued to thank, “all those who were involved from the discovery and development of delamanid to the approval of the drug. Otsuka will continue its efforts to increase the number of patients using the drug, and will continue contributing to tuberculosis treatment worldwide.”

Delamanid was approved in Japan, Europe, and Korea in 2014. The commendation was awarded to delamanid for its contribution to the medical care of TB, by addressing the pressing need for new effective treatments to the increasing occurrence of MDR-TB.

A doctor looking for a drug that helped his patients excrete only water unlike other diuretics inspired Otsuka Pharmaceutical to start researching for an agent to do just that.


It was discovered that this vasopressin V2 receptor antagonist may hinder the proliferation and enlargement of the cysts in the hereditary disease Autosomal Dominant Polycystic Kidney Disease (ADPKD).

Otsuka subsequently played a pivotal role in the clinical development of tolvaptan for ADPKD, and it is presently the only treatment option known to delay the long-term progression of ADPKD.

“I heard that this award commemorates ‘people’ who make achievements, and I am deeply moved by the fact that my life’s work involving the discovery and development of tolvaptan, which I spent 30 years on, has been recognized,” said Mr. Yoshitaka Yamamura, senior director of the Pharmaceutical Business Division.

“The ‘rugged’ drug discovery we started from scratch is now contributing to patients daily, and I am sincerely proud of that fact. I hope that new drug discoveries will be made for drugs that ‘originate in Tokushima and are the world’s first’.”

The commendation was awarded to tolvaptan for its contribution to the medical fields of heart failure and liver cirrhosis, as an agent with a new mode of action of water diuresis, as well as the only treatment option known to delay the long-term progression of ADPKD.

 
 
Apr 19, 2016

Read the full article with photos at 

https://www.otsuka.co.jp/en/company/globalnews/detail.php?id=226&date=2016-04-19

 

Otsuka and the Stop TB Partnership’s Global Drug Facility (GDF) announced a worldwide access plan for delamanid, one of only two medications approved to treat multidrug-resistant tuberculosis (MDR-TB) in the last 40 years.

The GDF is the largest supplier of quality assured TB treatments in the public sector, which gives it a unique position to catalyse uptake and expedite access to patients living in countries where TB medications are urgently needed. Launched in 2001 by the World Health Organization (WHO), the GDF was created out of a need to build an efficient system of procurement and distribution of high-quality TB drugs. Apart from procurement, the GDF provides a unique package of services, including technical assistance in TB treatment management and monitoring of TB drug use.

This innovative partnership with Otsuka opens access to over 100 low- and middle-income countries that are eligible for financing through the Global Fund to Fight AIDS, TB and Malaria and that follow WHO guidelines for the proper management of MDR-TB. As part of this partnership, GDF will also include delamanid in their Strategic Rotating Stockpile to ensure treatments get to people in need as quickly as possible. Apart from establishing a formalized partnership that ensures the supply of delamanid, Otsuka and GDF will work together to support communities with education, training, technical assistance, and TB advocacy activities.


Access to a reliable supply of high quality drugs is of great importance, as patients can develop TB drug resistance as a result of poor quality drugs and unreliable supply channels. Widespread drug resistance complicates and lengthens treatment, and as the disease is airborne just like other types of TB, it poses a major public health risk. Nearly half a million people each year develop MDR-TB and of those diagnosed and enrolled in treatment, only 50% are successfully treated.

This partnership is a key component of Otsuka’s wider strategy called the “FightTBack” initiative to scale up programmatic use of delamanid and fight TB through innovative R&D, ensuring responsible access to patients, optimizing patient management, and collaborative capacity building.

In line with its philosophy of addressing unmet medical needs, Otsuka is currently testing the first-ever pediatric MDR-TB formulation. Otsuka is continuing its research into innovative ways to fight TB, including development of mobile health technology for patients to receive treatment reminders on their smart phones and involvement in multiple research partnerships looking at shorter, more efficient and more patient-friendly ways to fight MDR-TB.

Feb 20, 2016

Read the full article with photos at 

https://www.otsuka.co.jp/en/company/globalnews/2015/0220_01.html

 

The Otsuka Museum of Art hosted the sixth Sistine Kabuki production – Yuriwaka Daijin: Ulysses – for 3 days, beginning on February 20, with two performances each day. As has been the case in past years, tickets sold out almost as soon as they went on sale. The performances were attended by 2800 persons from across Japan.

Incorporating Technology in Kabuki
The stage for this year's production was set up in the style of an arena, with elevated walkways leading off in all four directions. The stage was lit in various colors using blue light LED technology, made famous recently as the invention that received the Nobel Prize in physics last year. This year's performance was notable for the singing and dancing elements, which are not usually seen in kabuki, and for the use of slang words in the spoken dialogue, which drew cheers from the audience.

"Sistine Kabuki" productions are based on the themes of Japanese-Western collaboration and the creation of innovative kabuki theater. The current production – Yuriwaka Daijin: Ulysses – is a completely new work, a fusion of Greek mythology and traditional kabuki theater based on the tale of Yuriwaka Daijin, which is considered an ancient Japanese retelling of the Odyssey, the epic poem attributed to Homer.

Kazuo Mizuguchi returned as producer and director, and Kanjuuro Fujima returned as choreographer, and they collaborated with the Chinese opera performer Zhang Chunxiang to create a kabuki performance with musical accompaniment that incorporated both kabuki movements and Chinese opera-style percussion instruments. The presence of Yuuga Yamato, a former star of the Takarazuka Review theater troupe in Japan, playing two roles, one Eastern and one Western, was also a topic of great interest.

The protagonist, Yuriwaka Daijin, was played by Ainosuke Kataoka, making his fourth appearance in a row in Sistine Kabuki performances, and the roles of Princess Tachibana and the goddess Calypso were both played by Yuuga Yamato, making her first appearance. The roles of Takahime (the Spirit of the Hawk) and Hidetora's older sister Matsugae were both played by Kichiya Kamimura, who has appeared in Sistine Kabuki performances since their inception, and the role of Hidetora Ichiro was played by Tanenosuke Nakamura.

After the first performance, Ainosuke Kataoka said "I have sung in Sistine Kabuki productions before, but this year I was nervous singing because of Ms. Yamato's presence," and Yuuga Yamato said that "I had thought that only men appeared in kabuki, and I had played male roles before when I was with Takarazuka, but I was really grateful for the opportunity to appear in a kabuki production."

 

Dec 21, 2015

Read the full story with photos at 

https://www.otsuka.co.jp/en/company/globalnews/detail.php?id=225&date=2015-12-21

 

Dr. Gregory Fox from Sydney, Australia was presented the Young Innovator in Tuberculosis Research Award sponsored by Otsuka during the 46th Union World Conference on Lung Health in Cape Town, South Africa in December 2015.

Dr. Fox is an Australian respiratory physician and recipient of the CJ Martin Fellowship from the Australian Government. His research focuses on TB case-finding and multidrug-resistant TB in high-burden settings. Dr. Fox was the foundation country director of the Woolcock Institute of Medical Research in Vietnam from 2009 to 2013. During that period, in partnership with the Vietnam National TB Program, he implemented a randomized controlled trial (the ACT2 study), screening over 25,000 people for TB.

The project was innovative in its use of randomized controlled trial methodology and electronic tools that were developed especially for the trial and are scalable. Additionally, the project demonstrated the feasibility of centrally coordinated tracing of everyone who has come in contact with a person diagnosed with TB. Currently, Dr. Fox is an investigator on several ongoing public health and clinical studies of TB screening and prevention in Vietnam. He also works as a respiratory physician at Royal Prince Alfred Hospital in Sydney, Australia.

The Young Innovator in TB Research Award was established through a global partnership between Otsuka Pharmaceutical and The Union. The award is administered by The Union with a grant provided by Otsuka. Award recipients are selected by a panel of experts organised independently by The Union.

The purpose of the award is to stimulate the advancement of innovative approaches in TB control and patient care. The award is open to young clinicians who have documented achievements in the formulation and implementation of clinical and operational research in the field of TB or multidrug-resistant TB.

Aug 30, 2015

Read the full story with photos at https://www.otsuka.co.jp/en/company/globalnews/detail.php?id=224&date=2015-08-30

 

On the final day of the 15th IAAF World Championships held in Beijing, Mai Ito from the Otsuka Pharmaceutical Track & Field Team ran for Japan in the Women’s Marathon. Although the final day was cloudy compared to the blazing weather throughout the games, Ms. Ito ran confidently in hot conditions and finished first among all Japanese runners, earning her the right to run in the 2016 Olympics to be held in Rio de Janeiro, Brazil.

Ms. Ito focused on training and overcame harsh conditions in preparation for her second time competing in the World Championships. For this marathon, she concentrated on strengthening her muscles, with particular focus on training her lower body by performing squats with weights – a workout that she endured even after suffering a stress fracture in her foot.

Paying close attention to everyday diet and hydration prior to the competition was another factor contributing to her strong performance. She consumed more protein and carbohydrates, chose jellied food if she felt that this was a better choice for her digestion, and took amino acid supplements in addition to her meals to counter fatigue.

Careful hydration before and during running is just as important as daily diet. Ms. Ito chose ion supply drinks with optimum amounts of sugars to prevent dehydration throughout and to support her spurt in the latter part of her run.She was careful about hydration during training and at competitions, and the results of her daily adjustments were obvious from her performance at the marathon beyond the 30 kilometers point. While many runners down-paced by trying to catch up with the fastest spurting group, Ms. Ito’s determined run earned her a ticket to the upcoming Olympics after she finished 7th, the highest among Japanese runners.

Otsuka Pharmaceutical Track & Field Team’s athletes receive physical training and instructions on diet & hydration from instructors, coaches and a dietitian, all with a scientific approach tailored to each athlete’s physical features and conditions.

“It is crucial that each of our athletes recognize the science behind the various support they receive during their training and apply it towards international competitions,” commented Mr. Tadasu Kawano, Team Coach. “Ms. Ito is an ideal role model for other team members. She understands the data very well. Her physical abilities may be compared unfavorably with Western and African competitors, but her perseverance will surely lead her through the competition for medals.”

Ms. Ito joined Otsuka’s Track & Field Team, envisioning becoming a world-class athlete after she started running during her high school years. During the daytime away from track & field, Ms. Ito plays an important role in quality assurance at Otsuka Pharmaceutical Factory, Inc., and she finds pleasure in contributing to the wellbeing of people and patients around the world. “You can find many world-class athletes on the Otsuka Pharmaceutical Track & Field Team. We have an environment here that supports international competition,” says Ms. Ito. “I anticipated the Beijing World Championships race would be held in hot and harsh conditions, so I concentrated on not dragging fatigue after my rehearsals. I communicated actively with the staff members supporting me, to make sure my condition was monitored from all angles. What I have experienced during training for this marathon is an asset, and it will most certainly help me in conditioning towards the Rio de Janeiro Olympics to bring out the best performance of my career and to run in the top tier.”

On August 30, the same day that Mai Ito confirmed her place at the Olympics, a younger athlete from Otsuka’s team made a bright debut in Japan. Yui Okada, who joined Otsuka 4 years ago, championed in her very first full marathon in Hokkaido.

This was her second victory following a winning run in a half marathon, also her first time competing at that distance. “If there is anything I am uncertain of, I ask. I ask my teammates and dietitian what I should be doing to take care of myself. At Otsuka, I get the support I need to improve myself,” says the young debutante.

Otsuka’s younger generation athletes are striving for world-class results, and Otsuka Track & Field Team is proud of supporting promising young athletes through its vast knowledge and experience of wellbeing.

 

May 21, 2015

Read the full article with photos at:

https://www.otsuka.co.jp/en/company/globalnews/detail.php?id=220&date=2015-05-21

In ‘the city of sizzling woks’ with over 12,000 restaurants to dine at, you cannot avoid the scrumptious cooking aromas at any street corner. Hong Kong is a world-renowned gourmet paradise for its creative East-meets-West culinary delicacies, and for the accessibility there to imported foods from around the world. Some of the culinary pleasures of being in Hong Kong are exemplified by being able to relish a Cantonese breakfast and Mediterranean lunch, indulge in a treat with British-style afternoon tea, feast on French full course dinner followed by a midnight snack with Japanese munchies, all in one day.

 
Worrying about sugar and fat intake is the last thing you would want to do while enjoying your epicurean adventure in Hong Kong, which is why Otsuka’s first overseas launch of Kenja-no-shokutaku (The Wise Man’s Dining) Double Support in Hong Kong offers health-conscious gourmets a new option to curb absorption of sugar and lipids from deluxe diet, and thereby reducing the rise in blood glucose levels and triglycerides after meals. It comes in flavorless, odorless powder form which can be dissolved in any mealtime beverages or soup without affecting their flavor.(More product details in Chinese can be read here at a local website: www.wisemansdining.hk)
 
Today, as more than a third of Hong Kong’s residents are classified overweight or obese, consumers are seeking out healthier foods and beverages to use on a daily basis, which accounts for the rapid expansion of the city’s diet-oriented foods market. Higher health awareness also influence people to choose functional products, such as sports and energy drinks, to promote a more active lifestyle as a way to avoid weight gain.
 
In the spring of 2015, Otsuka launched two more nutraceutical products in Hong Kong, which were presented at a media event held in late May, featuring actress Ms. Myolie Wu, and an internationally active dietitian, Ms. Mylene Khoo, both whom are well known icons of well-being.
 

RONAMIN C drink is one of the three items launched and it marks its 50th year anniversary back in Japan where it originates. At the event, Ms. Myolie Wu expressed how happy she was to be able to enjoy the made-in-Japan ORONAMIN C again in her homeland, which she was fond of during her residence in Japan. The 120ml flavorful carbonated drink fortified with the vitamin C equivalent of 11 lemons, vitamin B-complex and other nutritional elements, has been refreshing and energizing people of all ages for half a century. (Energizing tips of ORONAMIN C in Chinese can be read here at a local website: www.oronaminc.hk)

A perennial taste combo favorite, ‘Almond & Chocolate’ flavor, joined the SOYJOY line-up in Hong Kong. Chewy baked bar SOYJOY is made from 100% soybean flour and contains no wheat. The passionate team from Otsuka Pharmaceutical in Hong Kong will continue awareness building campaigns of the benefits of including low glycemic index foods in healthy diets, through the marketing of SOYJOY in various fruit and nut. (For more information on Low Glycemic Index, a numerical indication of how much your blood glucose level rises after a meal, visit our English webpage “Everything You Need to Know about GI”. Local SOYJOY product information in Chinese can be read here: www.soyjoy.hk)

The recent splashy debuts of Otsuka’s nutraceutical products demonstrate how the company’s belief in innovating nutritional products with scientific backing is taking root in Hong Kong. With almost two decades of experience in the city with pharmaceutical business too and therefore a strong presence in the local medical industry, Otsuka is hoping to touch the heartstrings of many more health conscious people in Hong Kong.

 

Apr 5, 2015

Read the full article with photos at:

https://www.otsuka.co.jp/en/company/globalnews/detail.php?id=217&date=2015-04-05

Otsuka is proud to be the lead supporter of the National Conference of State Societies’ (NCSS) 67th Cherry Blossom Festival events, including their flagship Cherry Blossom Princess Program. Otsuka has pledged its recurring support to the NCSS Cherry Blossom Events for three consecutive years, to demonstrate the company’s commitment to empowering young women to aspire to accomplish their goals and become the leaders of the next generation.

The National Cherry Blossom Festival is held in Washington, DC each spring, commemorating the gift of the cherry blossom trees, which symbolizes the friendship between the peoples of the United States and Japan. The cherry trees were first gifted to Washington, DC in 1912 from Mayor Yukio Ozaki of Tokyo. 2015 marks the 100th anniversary of the United States’ reciprocal gift of flowering dogwood trees to the people of Japan. For Otsuka, as a Japanese company with operations in the United States, supporting an event that commemorates this enduring friendship is especially appropriate. William M. Christian, the President of NCSS complimented Otsuka, noting, “NCSS is proud to have continuously administered the Cherry Blossom Princess program, including the US Cherry Blossom Queen, since 1948. We are particularly grateful for the support of our chief sponsor, Otsuka America Pharmaceuticals, Inc. With our shared ties to the Japanese culture, Otsuka is a natural partner for the NCSS, and this collaboration portends the continued success of our iconic program of empowering young women and promoting cultural exchange."

The Cherry Blossom Princess Program has been held annually since 1948, with the mission of “Aspiring Leadership and Empowering Young Women.” The program offers young women from across the US and around the world the opportunity to participate in community outreach, personal development, educational, leadership, cultural and networking activities. Otsuka’s support to the NCSS’ Cherry Blossom Festival events inspires the many activities for the Princesses, which promote personal growth and foster leadership. Former Cherry Blossom Princesses include US Senator Lisa Murkowski of Alaska, US Senator Shelley Moore Caputo of West Virginia, and Lynda Johnson Robb, the former First Lady of Virginia and daughter of former US President Lyndon B. Johnson. These accomplished women are a testament to the program’s success in encouraging young women to achieve the highest caliber of success.

 

 

 

Apr 1, 2015

Read the full story with photos at:

http://www.otsuka.co.jp/en/company/globalnews/detail.php?id=221&date=2015-08-13

 

Otsuka Australia Pharmaceutical (OAP) opened its first Australian office in Sydney in April, 2015.

Kangaroos & koalas, the Great Barrier Reef and shiraz wine are some of the more familiar images of Australia to people elsewhere in the world, but there is much more in this continental country of more than 23 million people. Australia is home to world class science, and a collaborative research environment that has made life sciences one of the biggest and most rapidly evolving industry. Like other developed countries, Australia’s population is gradually aging and experiencing a rise in chronic illnesses, including mental disorders. These were some of the factors that led Otsuka to put down stakes in Australia for the long term. Otsuka is seeking to apply constructive approaches to these challenges, to meet the unsatisfied health needs in Australia and neighboring countries.

How Otsuka’s direct presence in Australia will make a difference

Rather than being bound by industry customs and trying to compete head-to-head with everyone else, Otsuka has consistently drawn on original thinking.

OAP has started its operation with a focus on central nervous system disorders – an area which includes conditions such as schizophrenia, where patients in Australia await better treatments. Nick Malik, Sales and Marketing Manager, CNS portfolio noted, “Schizophrenia and other mental illnesses continue to be a burden on too many Australian families. Otsuka is a leading firm in the challenging area of mental health, and our experienced and dedicated team at OAP, together with our alliance partner Lundbeck, are eager to help improve the lives of people with mental illness in Australia.”

The head office is in Chatswood, an area in proximity to the beautiful beaches of Sydney’s north coast, and the world famous Sydney Harbour Bridge. In keeping with Otsuka's heritage, employees have been learning Japanese and embracing the subtle cultural and business differences. It goes without saying the team enjoys Japanese cuisine at every opportunity.

“We are proud to become part of the healthcare community here in Australia and beyond in Oceania.” says Masamitsu Kitada, Managing Director of OAP. “Otsuka’s presence aligns the company’s extensive global experiences with the rich and diverse local cultures and customs in Australia. With dream and passion, our mission is to deliver better treatments and outcomes to patients in the region through Otsuka’s original and innovative products.”
Apr 1, 2015

Read the full story with photos at:

https://www.otsuka.co.jp/en/company/globalnews/2015/0311_01.html

 

Ms. Mai Ito, a member of the Otsuka Pharmaceutical Track & Field Team, has been selected to represent Japan in the women’s marathon event at the 15th IAAF World Championships in Athletics to be held in Beijing.
The marathon will be on August 30, 2015. This will be her second time to compete in the World Championships in Athletics, after participating in the 2011 competition.

Top 2 in Nagoya Women’s Marathon paved the way

At the Nagoya Women’s Marathon, a qualifying event for Japan’s national team going to the IAAF World Championships in Athletics, Ms. Ito finished with a personal best time of 2 hours, 24 minutes, 42 seconds.

Despite this excellent result Ms. Ito said, “Not achieving my goal of placing first among the Japanese runners was frustrating.” At the World Championships in Athletics, she is aiming to be the best runner from Japan, and after that, to make a mark on the world stage.

“To accomplish that, I want to properly build on my training starting now, so I can give it my all at the World Championships,” she said, expressing her aspirations going forward.

Mai Ito’s journey to being selected for the World Championships

Being highly ambitious and training for competitions based on a scientific approach is a key feature of the Otsuka Pharmaceutical Track & Field Team. Upon hearing that Ms. Mai Ito would compete in the World Championships in Athletics as she had hoped, team coach Mr. Tadasu Kawano commended her: “She is an athlete who always aspires to go higher, and is keenly aware of what it takes to compete—that attitude is her strength.”

Ms. Ito ordinarily works at the Otsuka Pharmaceutical Factory, where she is involved in quality control procedures. Her main duties include handling documents and inspecting product appearance. As an employee of a pharmaceutical company, Ms. Ito has an important role in ensuring that high-quality products are provided to patients and consumers who care about maintaining good health.

Regarding the Otsuka Pharmaceutical Track & Field Team she said, “I can train for competitions with a lot of motivation because the team provides me with an environment that helps me become stronger.” The team helps Ms. Ito perform at her best by managing her physical condition based on various kinds of data and by making use of scientifically-based products.

25 Years of Track & Field Team History

The Otsuka Pharmaceutical Track & Field Team was founded in 1990. As a basic principle, it strives to develop athletes so they can succeed not only in Japan but also internationally. As of April 2015, it consists of a men’s team of 17 athletes (including the team coach, who is also a member), a women’s team of 10 members, and a staff of eight. It is based in Naruto City, Tokushima Prefecture, which is the birthplace of the Otsuka Group.

In the past, the team’s members have competed in international tournaments, including some of the world’s most competitive marathons. In Japan, the members of the men’s team regularly participate in the country’s premiere running events, such as the New Year Ekiden, while members of the women’s team compete in long-distance events like relays and race walking.

Mar 24, 2015

Read the full story with photos at:

Otsuka working Towards Overcoming Tuberculosis

On March 24th – World TB Day – we are reminded of the 9 million people who become infected with tuberculosis (TB) every year, their challenges and their hope for cure. We at Otsuka remember this every day.

It is the driving force behind our commitment to discovering new tools to eliminate TB in our lifetime. As the world’s leading private investor in TB research and development, it has been our goal for the past 40 years to find new, effective solutions to eliminating this disease that claims 1.5 million lives a year.

We know that TB can affect anyone, anywhere in the world. That is why this year, we focus on those who are truly on the front lines of this disease – the healthcare workers, the patients, and their families. Each day this week we will profile stories of those who are making a difference in this fight and the inspiration they provide to others here.

People such as Dasha and Grisha Lavrushiny, a young married couple from Russia, who have both struggled with TB, including the extensively-drug resistant form of it, but in the end have won the battle. Today, they are helping others receive correct diagnosis and treatment.

Li Lulu, a young mother from China, developed TB meningitis, a particularly dangerous type of TB, right after giving birth. The encouragement and support of her family had given her the strength needed to complete treatment and today she is cured.

The support of loved ones and the dedication of healthcare workers on the frontlines of the battle, such as Stuart Pancho, a registered nurse from the Philippines who leads trainings for other healthcare workers. The personal bonds they have established with their patients have proven essential to their treatment success.

Though treatment for TB may be complicated and lengthy, it is a curable disease. Yet an estimated 3 million people a year go undiagnosed or untreated. Much progress remains to be done until every person is correctly diagnosed, treated and cured. We at Otsuka are committed to continuing our efforts so that, ultimately, we can live in a world free from TB.

Feb 27, 2015

Read the full story with photos at: http://www.otsuka.co.jp/en/company/globalnews/2015/0227_01.html

 

The late chairman of Otsuka Holdings, Akihiko Otsuka (who died in November 2014), has posthumously received the 18th Princess Chichibu Memorial Award for Distinguished Service to Tuberculosis Elimination. This award honors individuals and organizations that have made great achievements in tuberculosis prevention. The ceremony was held on February 27, 2015 at the 66th national convention of the Japan Anti-Tuberculosis Association, and Otsuka Holdings Vice Chairman Ichiro Otsuka accepted the award in place of the late Chairman Akihiko Otsuka.

History of Princess Chichibu Memorial Award

The Japan Anti-Tuberculosis Association holds a national convention every year on March 24, World Tuberculosis Day. In addition, at the bequest of Princess Chichibu, who served as president of the Anti-Tuberculosis Association for more than half a century, the Princess Chichibu Memorial Tuberculosis Prevention Awards were established to memorialize her name and to honor individuals and organizations from Japan and abroad that have made significant contributions to tuberculosis prevention. Each year, on the day of the national convention, the awards are presented with Her Imperial Highness Princess Akishino, association president in attendance.

 During the 1960s, when the tuberculosis epidemic in developed Western countries subsided, interest in development of anti-tuberculosis drugs withered rapidly even though the disease continued to spread in developing countries. Akihiko Otsuka, who became president of Otsuka Pharmaceutical Co., Ltd. in the 1970s, realized that tuberculosis was the most serious among Asian health problems, and concluded that the development of more powerful anti-TB drugs was of critical importance for Asian pharmaceutical companies. Following the founding of company’s first drug R&D lab in 1971, he overcame company-internal resistance to make significant investments over the next 30 years as the company continued R&D on anti-TB drugs.

As a result, Deltyba® (delamanid is the generic name) was discovered in 2002, and went on to receive regulatory approval in Japan and Europe in 2014 as a new anti-tuberculosis drug. This innovation arrived 40 years following Rifampicin, the first anti-tuberculosis drug, and 55 years following the discovery of kanamycin in Japan in 1958. The development of delamanid, a drug that has shed considerable light on the treatment of previously intractable multidrug-resistant tuberculosis, and which has significant future potential in the treatment of this serious medical condition, was a manifestation of the company leadership’s clear intent and strong mission.

Otsuka Holdings Representative Director and Vice Chairman Ichiro Otsuka commented, “On the occasion of receiving of this prestigious award, I extend my heartfelt thanks on behalf of my late father. We are gratified that it is useful for the treatment of patients around the world who suffer from multidrug-resistant tuberculosis, as this is a fulfillment of the Otsuka Group’s corporate philosophy to contribute to the health of the world’s people."

Otsuka Pharmaceutical has launched a new anti-tuberculosis drug in Japan and Europe for treating multidrug-resistant tuberculosis, which is a public health issue that has become a global threat. In the future, we will continue working to achieve our long-term goal of worldwide elimination of multidrug-resistant tuberculosis.

Feb 22, 2015

Read the original story with photos at:

https://www.otsuka.co.jp/en/company/globalnews/2015/0222_01.html

Otsuka has supported the Tokyo Marathon, one of the largest city marathons in Asia, for 9 years in a row, since its inception. This year's running of the Tokyo Marathon was held on February 22.

The Otsuka Group, a total health care company that handles everything from functional foods and beverages to human pharmaceuticals, provided 36,000 runners rehydration and nutritional assistance, and was the first single corporate group to do so in the history of the Tokyo Marathon.

Tokyo Marathon is one of the six largest and most renowned marathons in the world, and only one Asian race to be recognized as such. 113 countries and regions participated in this year’s marathon, with about 5,000 foreign participants (14% of total runners). The most athlete participants came from Taiwan, with 1,367.

POCARI SWEAT is now available in 18 countries and regions making it a very familiar and trusted brand for worldwide athletes participating in this international event.

In a marathon, when each runner's body is pushed hard for an extended length of time, it is extremely important to get adequate hydration and nutrition before, during, and after the race in order to prevent the body from becoming depleted of water and nutrition and to ensure that the race can be finished safely.

Based on research conducted by Otsuka's own Sports Nutrition Institute, Otsuka Pharmaceuticals provided the runners with various products before the race (Amino-Value, providing BCAA), during the race (POCARI SWEAT, providing water and electrolytes), and after the race (Calorie Mate, providing 5 major nutrients, including protein and sugars). Otsuka provided water and nutritional replenishment to 36,000 runners from around the world both at the EXPO and on the day of the race.

Early in the morning, with a light rain falling, around twenty Otsuka employees, along with volunteers, prepared Amino-Value and Calorie Mate Jelly for runners before the start of the race in order to provide them with the amino acid BCAA and 5 major nutrients.

At stations along the course, runners received POCARI SWEAT to provide them with well known water and electrolytes. In the marathon, when the runners were sweating even in the cold, those runners who remained adequately hydrated were able to perform their best and complete the circuit around Tokyo. Runners who crossed the finish line were handed packages of Calorie Mate to allow them to easily replenish their depleted stores of 5 major nutrients.

 

Jan 30, 2015

Read the full story with photos at:

https://www.otsuka.co.jp/en/company/globalnews/2015/0130_01.html

25th Asia Business Conference

Mr. Daesik Eom, Senior Operating Officer at Otsuka Pharmaceutical was invited to speak at the University of Michigan’s 25th Asia Business Conference in US which has brought leaders of Asia and multinational companies together to discuss, debate, and dialogue about trends in Asia.

Otsuka Pharmaceutical was invited among other world class companies to be part of the conference because of its successful and sound global business recognized in the US as well as throughout the Asia-Pacific countries.

Past conferences have featured speakers from multinational corporations such as Google, Yahoo, Ford Motors, Logic Solutions, DoCoMo, Merrill Lynch, Johnson & Johnson, Mitsubishi Motors, General Motors, Shell, Nike, Satyam, Morgan Stanley, Dow Chemical, Baxter Healthcare and Pfizer.

Mr. Eom spoke at one of the regional panels on Japan, introducing Otsuka Pharmaceutical as a global company with a goal of “creating new products for better health worldwide”

Born in South Korea, he graduated from the Department of Forest Sciences, College of Agriculture and Life Sciences, at Seoul National University. He then joined Otsuka Pharmaceutical Co., Ltd.

At the age of 35, he became President and Representative Director of Korea Otsuka Pharmaceutical Co., Ltd. He was the youngest president for a pharmaceutical company in Korea at that time. Accomplished a great achievement in Korea, he moved to Japan and works for Otsuka Pharmaceutical as his current position in Japan.

Jan 29, 2015

Read the full story with photos at:

https://www.otsuka.co.jp/en/company/globalnews/2015/0129_01.html

FoodState is a whole food supplement company based in Derry, New Hampshire. Since its founding in 1973, FoodState has become an innovator in whole food based supplements and has been recognized for great products and strong brands in the natural and healthcare practitioner channels.

One aspect that sets FoodState apart from the competition is its approach to creating nutrients by starting with fresh or frozen whole foods - the focus of its leading brands, MegaFoodTM and INNATE Response FormulasTM.

For MegaFoodTM, everything starts with real farm-fresh fruits, vegetables and botanicals that are used as the base for the brand’s dietary supplements. The tagline “fresh from farm to tablet” means fresh and local foods are sourced from trusted farmers, and then the nutrients and wholesome supplements are made using a one-of-a-kind, proprietary Slo-Food ProcessTM.

As part of this unique approach, FoodState’s MegaFoodTM and INNATE Response FormulasTM, are recognized leaders in their respective channels and known for several key differentiators, including partnering with organic and sustainable farms to source fresh and local foods, and purchasing approximately 500,000 pounds of produce a year from farmers.

FoodState mills and purees whole foods, then integrates additional nutrients to guarantee potency levels. This integration of whole foods and individual nutrients is then dried with the utmost care using refractance window drying technology, also part of the Slo-Food ProcessTM.

The Slo-Food ProcessTM is a slower way of making whole food supplements. It can take 236 hours to make just one batch of finished product. Each and every step, from farm to tablet, was designed with one ultimate goal in mind—to create supplements that make a noticeable difference on consumers’ journey toward optimal health while staying true to the intention of food.

The FoodState team hand crafts each and every product in their own facility right down to the hand-packing of bottles for shipment.

Jan 21, 2015

Read the full story with photos at:

https://www.otsuka.co.jp/en/company/globalnews/2015/0121_01.html

Otsuka America Pharmaceutical, Inc. (OAPI), its alliance partner Lundbeck, the National Alliance on Mental Illness, and the National Council for Behavioral Health joined in two years ago to organizeConnect 4 Mental Health®. It is an initiative that aims to help communities throughout the United States implement local approaches that provide additional support for those with serious mental illness.

Connect 4 Mental Health (C4MH) encourages community-based organizations, such as emergency services, law enforcement, and public housing, to work with mental healthcare providers and advocates to develop programs that support the estimated 6% of Americans living with serious mental illness.

“Our hope is that Connect 4 Mental Health will ignite a movement inspiring individuals and organizations to collaborate in order to help improve the lives of people with mental illness, one community at a time,” said Donna Erwin, Director, Advocacy and Policy, OAPI.

C4MH has identified four areas of focus that may help communities address mental illness locally: 1) Early Intervention, 2) Creative Use of Technology, 3) Integration of Services, and 4) Continuity of Care.

To recognize organizations that have shown good examples of work in these areas, C4MH implemented a ‘Community Innovation Awards’ program. Winners received a 10,000 USD award and access to a one-on-one mentorship program.

The winning organizations chosen for the 2014 awards:
Early Intervention: NAMI of Collier County (Naples, Florida)
Creative Use of Technology: Crisis Text Line (New York City)
Continuity of Care: Charleston Dorchester Mental Health Center (Charleston & Summerville, South Carolina)
Service Integration: Robert Young Center (Moline, Illinois)

Jan 16, 2015

Read the full story with photos at:

https://www.otsuka.co.jp/en/company/globalnews/2015/0116_02.html

Otsuka’s commitment to fight TB

Infectious disease experts from around the world gathered in Okinawa, Japan in mid-January for the second Nikkei Asian Infectious Diseases conference. Otsuka signaled its ongoing commitment to the fight against TB by again co-sponsoring the conference.

Game changers

Asia, which accounts for more than two-thirds of the world’s TB burden, clearly must be at the center of the goal to defeat TB globally. The introduction of a new drug for multidrug-resistant TB, as well as1new technologies to diagnose TB and its drug-resistant strains, are perceived as potential “game changers” in the fight against TB in the region.

However, one prominent specialist present noted that a badly designed MDR-TB program may actually cause more harm than having no program at all, citing the need for high-quality drug sensitivity testing and precise follow-up with patients.

This mixture of new optimism and renewed concern about TB prompted the event organizers to select TB as a key theme of the conference.

TB drug development needs to be simpler

Hiroshi Ishikawa, Ph.D. (right) Fellow, Medicinal Chemistry at Otsuka, who was one of the key members of the Otsuka team that developed the drug delamanid, spoke with stirring passion at the conference about the scale of the challenge involved in creating a new TB drug. It included the study of over 14,000 compounds across two decades, something that a single chemist could not hope to accomplish in 100 years.

With an eye toward the future he noted that TB drug development will need to be simpler to reduce costs and facilitate broader access by patients.

Dr. Ishikawa also drew the attention of the audience to broader issues in the fight against TB. One is the need for improved diagnostics, especially kits that can rapidly measure TB bacilli susceptibility to drugs and biomarkers that can differentiate active from latent cases.

Max Yoshitake (left), Leader, Global TB Team was called on by one of the session moderators for his insights on issues such as latent TB, which is present in over 30% of the world’s population. Mr. Yoshitake noted that one important challenge for Otsuka and others will be to shorten the duration of treatment to just a couple of months.

Overall, a sense of cautious optimism filled the conference room. This was suggested by the nearly 45% decline in the TB mortality from 1990 to 2013, partly due to the DOTS (Directly Observed Treat Short Course) and Stop TB strategies. Looking forward, new diagnostics and drugs to treat the most difficult forms of the disease also hold promise. But no one was ready to say that the victory over TB, a disease as old as humanity itself, is near at hand.

Jan 15, 2015

Read the full story with photos at:

https://www.otsuka.co.jp/en/company/globalnews/2015/0116_01.html

Otsuka Pharmaceutical Europe Ltd. (OPEL) has been recognized by Cambridge University as an employer that positively encourages diversity, integrity and innovation by encouraging our employees to be creative and to think unconventionally.

Selection process

During the ‘Employers of Choice’ selection process, Cambridge University shortlisted 60 employers out of 400, focusing on their commitment to a set of procedures and values including: engagement; talent management; providing opportunities for learning & development; diversity; a commitment to wellness and sustainability, governance and transparency.

‘The secret to nurturing fruitful growth – dare to be different’

Otsuka Europe’s selection as an ‘Employers of Choice’ by the University has resulted in an article entitled ‘The secret to nurturing fruitful growth – dare to be different’ in the prestigious ‘Cambridge: Inspiring Leadership & Innovation’ publication.

This publication is widely circulated, both in a printed and e-book format, to over 20,000 Cambridge students, members of the Cambridge Alumni association, UK and government departments, more than 30,000 educational establishments, 17,000 higher and further education institutions worldwide, international accreditation bodies and other global business audiences.

This article focuses on Otsuka’s history and growth, our creative and innovative approach, as well as, highlighting some of the key differences between Otsuka and other pharmaceutical and nutraceutical companies.

‘We’ve never been afraid to do things differently, which sets us apart in the marketplace and helps us stand out.’ Ole Vahlgren, CEO & President – Otsuka Europe.

Dec 19, 2014

Read the full story with photos at:

https://www.otsuka.co.jp/en/company/globalnews/2014/1219_01.html

Nutraceuticals are one of Otsuka Pharmaceutical's core businesses, and include products such as POCARI SWEAT and Calorie Mate that were developed based on scientific principles in order to improve people's health.

The Saga Nutraceuticals Research Institute (SNRI) (left) conducts research aimed at developing new products and creating added value for products in a wide range of situations.

At the Saga Research Center, in 2014, the 30th anniversary of its founding, the Center renovated its artificial climate chamber. The chamber's temperature and humidity can be controlled with a high level of precision, and can also be used to create a low oxygen environment.

As with "exercise and nutrition," the Center's research topics are selected with an eye towards tackling various health issues. In recent years, "women's health" has been added to the list of the Center's areas of focus.

The research has found that one of the keys to these benefits are the female hormone-like effects of equol, a product of the metabolism by intestinal bacterial of daidzein, one of the components found in soy isoflavones. Through its research into equol, Otsuka Pharmaceutical became the first in the world to identify lactic acid bacteria that could be used in food products, out of those intestinal bacteria that work to produce equol. EQUELLE is a new soy-based product that helps women maintain and enhance their health, helping them lead a sparkling life during and after the menopausal transition.

Major Research Results Reported to Date:

・Recovery of plasma volume through the consumption of ion drinks when dehydrated
・Effects on the intestinal environment of ingesting beverages containing dietary fiber
・Maintaining performance by taking BCAA before exercise
・Water replenishment during long airplane flights
・Effects of a balanced diet on brain function
・The discovery of equol-producing bacteria, and the effects of equal on menopausal women

Otsuka Pharmaceutical will continue to conduct cutting-edge research into water and nutrition replenishment in the course of people's daily activities in order to formulate new proposals that can contribute to improved health.

Since its inception in 1984, the Saga Research Center has produced a number of products based on novel concepts and information, including EQUELLE, energen, and FIBE-MINI.

For more than 30 years, the Saga Research Center has been conducting innovative research with the goal of improving people's health and providing information to people around the world.

When the Saga Research Center, which was Japan's first clinical exercise and nutrition research institute, was founded, Mr. Hitoshi Hariu (right), who was involved in the development of Calorie Mate and was a pioneer in the field of "exercise and nutrition," led the effort to found the Center, and was appointed its first director.

Mr. Hariu visited universities across Japan based on the thinking that "new fields require new people," and when the Center opened in 1984, it did so with a staff of nine.

The second director of the Center was Hideaki Kohri, Ph.D. (left), a pharmaceutical researcher. Dr. Kohri instructed the Center's researchers to travel the world and experience for themselves the ways in which people in other cultures and situations get nutrition. The Center's researchers have formulated and verified various new research hypotheses.

On the Center's thirtieth anniversary, Mr. Hitoshi Hariu said, "The strength of Otsuka Pharmaceutical's products lies not only in their image, but also in scientific evidence. I would like our researchers to continue to utilize the Center's unique environment, which encourages wide-ranging research, to develop products that are useful to people around the world."

In addition, Dr. Hideaki Kohri said, "Pharmaceutical product research is performed based on when people are at rest. However, both healthy people and patients need activities according to each person's body condition. I would like the Center to take advantage of both the knowledge that is obtained in pharmaceutical research and the experience that is gained in the real world in an attempt to answer the question ‘What kind of activities we should take, when and what type of nutrition we should take?’ to continue to conduct ground-breaking research related to sports and nutrition that can contribute to people's health."

 

Dec 4, 2014

Read the full story with photos at:

https://www.otsuka.co.jp/en/company/globalnews/2014/1204_01.html

The 46th Annual Meeting of the Swiss Society of Nephrology (SSN) took place on December 4th and 5th in Interlaken, Switzerland.

Over 300 nephrologists, researchers, and nurses, including all the Swiss KOLs attended the meeting which consisted of plenary sessions, oral communications, poster sessions and satellite symposia.

New affiliate Otsuka Pharmaceutical (Switzerland) GmbH (OPCH)

was present at the meeting with one of the first ADPKD disease awareness booths in Europe.

The booth combined elements of the disease awareness campaign, market access, and PAG engagement. Also several leave pieces have been distributed and a survey on patient journey has been carried out with some of the physicians.

Attendees of the congress were highly interested to learn more about Otsuka and its engagement in ADPKD. Especially in the lunch breaks the booth was well frequented. The exchange with many attendees has shown that the awareness of ADPKD among Swiss nephrologists is very high and the unmet medical need in this disease is largely recognized.

The presence of OPCH with a disease awareness booth marks a successful milestone in the ADPKD awareness campaign. We were able to connect the unmet needs in ADPKD to the commitment of Otsuka, and position OPCH as the new player in the disease area of nephrology in Switzerland.

We are looking forward to our presence at the 2015 Swiss Nephrology Congress.

Nov 30, 2014

Read the full story with photos at:

https://www.otsuka.co.jp/en/company/globalnews/2014/1130_01.html

The idea to have Santa visit Tohoku children affected by the 2011 Great East Japan Earthquake came when a group of students from Kanto Gakuin University visited a preschool in Kamaishi City in Iwate Prefecture. It was a summer picture book reading event to provide emotional support and relief to the children affected by the natural disaster. At the end of their visit, the children said, “When you come back, bring Santa Claus!”

Planned and implemented by the Kanto Gakuin University students in December 2011, the Santa Project was born. This was in collaboration with organizations in Finland, including the traditional choir Belcanto and Santa Claus who is officially approved by Finland’s Santa Claus Village.

Since then every year, Santa Claus from Finland visits children in various areas destroyed by the earthquake and tsunami passing out gifts to bring them holiday cheer.

The Santa Project receives funding from a wide range of Japanese companies, including Otsuka Pharmaceutical. Volunteer students as well as Otsuka Pharmaceutical employees helped package SOYJOY bars and Calorie Mate in gift bags for Santa to give the children.

The Santa Project provides emotional support and relief by promoting exchange events between survivors of the disaster, including children, and people from outside the area, to ensure that the event does not fade from memory.

Santa Project volunteers travel with disaster survivors to Okinawa and Niigata, which itself has suffered from earthquake disasters in the past, Hokkaido, and other locations in Japan to promote cultural exchange between the people in these areas and the disaster survivors.

Volunteers in the Santa Project hope that it can bring people together so that they can bring each other hope and joy, in the same way that the idea of Santa Claus brings hope and joy to children around the world.

Nov 27, 2014

Read the full story with photos at:

https://www.otsuka.co.jp/en/company/globalnews/2014/1127_01.html

New Office Space For Creative Thinking

Otsuka America Pharmaceutical, Inc. (OAPI), and Otsuka Pharmaceutical Development & Commercialization, Inc. (OPDC), recently put the finishing touches on a new, innovative office space in Princeton, New Jersey.

The space has been thoughtfully designed with an open floor plan that inspires creativity and facilitates everyone’s ability to connect and collaborate without barriers.

Otsuka’s Culture Reflected in Design

The unique design of the office reflects Otsuka’s culture, values, and vision. It provides employees with an optimal environment for brainstorming, camaraderie, and teamwork across the two companies.

A central, open staircase connects all four floors of the new building to encourage movement between floors and to create a sense of unity across the organization. Individual desks are arranged in a more open floor plan, creating an energizing team atmosphere.

In addition, through features such as flexible seating arrangements, meeting rooms of all sizes, open common areas, and a colorful interior décor, the unique workplace design effectively addresses Otsuka’s three main priorities: collaboration, big venture thinking, and innovation. And a large amount of natural light can be found on each of the building’s four levels, a feature that was identified by employees as very important.

Nov 27, 2014

Read the full story with photos at:

https://www.otsuka.co.jp/en/company/release/2014/1121_01.html

Nutrition & Santé Inaugurates New Factory
Expanding Production Base of the French Leader in Functional and Dietetic Foods

  • Otsuka Group member Nutrition & Santé (N&S), based in the Midi-Pyrénées region of southern France, is the French leader*1 in health and dietetic food, with a distribution network extending to more than 40 countries.
  • Easy to consume in the midst of a busy urban lifestyle, bar-type nutrition products including Milical are showing steady growth, with sales increasing by approximately 10% year-on-year. A new factory at the company’s site in Revel, France, will produce bar-type nutrition products for the European and Japanese markets.
  • Ninth production facility for the N&S Group will expand production capacity of bar-type items by 1.7 times

Otsuka Pharmaceutical Co., Ltd. (Head office: Tokyo; President: Taro Iwamoto) subsidiary Nutrition & Santé (N&S; Headquarters: Revel, France) has completed construction of a new production facility at N&S Group headquarters in the Midi-Pyrénées region of France. The ninth production facility for the N&S Group, the new factory was inaugurated with a ceremony on November 20, 2014. The new factory strengthens the N&S industrial base by expanding production capacity for Milical and other bar-type nutrition products for the European and Japanese markets.

The three existing factories in Revel currently account for approximately one third of N&S production capacity, including all bar-type products. In recent years, protein bars and other diet foods that can be easily consumed in the midst of a busy urban lifestyle are growing in popularity in France, and N&S bar-type products including Milical have posted steady growth of approximately 10% year-on-year. Constructed in response to this demand, the new factory, dedicated to production of bar-type products, will expand production capacity by approximately 1.7 times. Products from the new factory will be distributed in more than 30 countries, including Japan.

 

Nov 18, 2014

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https://www.otsuka.co.jp/en/company/globalnews/2014/1118_01.html

"Mr. Otsuka, you are a true friend of France," said Mr. Charles-Henri Brosseau, the Consul General of the French consulate in Kyoto, Japan, in fluent Japanese, to the late Chairman Akihiko Otsuka* on November 18 of last year.

The occasion was a momentous ceremony held at the Rihga Royal Hotel in Osaka to present Mr. Otsuka with the Officer Order of the Legion of Honor on behalf of the President of France.

 

The Order of the Legion of Honor was established in 1802 by Napoleon Bonaparte. It is France's highest award, and is bestowed in times of peace and war on military personnel and private citizens who have made great contributions to France in areas such as culture, science, industry, business, or creativity.

Mr. Otsuka was awarded the Order for his work promoting the Japan-France relationship through his extensive business activities in France over many years.

The ceremony consisted of an awards presentation speech by Mr. Charles-Henri Brosseau and then the actual presentation of the award, followed by an acceptance speech by Mr. Otsuka.

Everyone present, including top Otsuka Group executives, offered Mr. Otsuka their heartfelt congratulations, and many congratulatory messages were sent to the ceremony by persons not in attendance.

Otsuka Holdings President, Mr. Tatsuo Higuchi, opened the banquet that was held following the awards ceremony with a toast "To Chairman Otsuka, and the continued development of the Otsuka Group".

Acceptance Speech by Chairman Akihiko Otsuka

I am deeply honored to receive, from a representative of the President of France, France's highest award, the Officer Order of the Legion of Honor. I would like to express my sincerest thanks to you all.

In our efforts to contribute to the better health of people worldwide, and to continue our evolution into an international total health care company, the Otsuka Group has been actively expanding our business in Europe.

Specifically, most of our investments in Europe have been in France, which has become an important base of operations for the Otsuka Group. We feel that we have been rewarded for energetically pursuing new business opportunities in the field of medicine and foods and beverages while retaining our respect for and desire to learn from the traditions and culture of France, in our efforts to help the citizens of France realize the universal desire of people everywhere for improved health.

Our business activities in France have played such a prominent role for the Otsuka Group thanks to the support and cooperation of many people, including the government of France, for which we are truly grateful. Thinking back on the history of our operations since their initiation in France to the present day, being chosen to receive this most honorable award fills me with emotion and gratitude.

The Otsuka Group intends to continue working to promote creative business activities and to do our utmost to maintain and improve Japan's relationship with France. It is my sincere wish that we can all continue to work together to improve this relationship, and I look forward to your further guidance and encouragement in the future. I thank you from the bottom of my heart.

Today has been a great honor.

Mr. Charles-Henri Brosseau's Introductory Remarks (excerpted)

I am honored to stand before you today to present the Officer Order of the Legion of Honor to Mr. Akihiko Otsuka, a leading Japanese industrialist and international businessman – and a close friend of France.

Mr. Otsuka's company was founded in 1921 in Tokushima, Japan, and is now one of the most prominent business groups in Japan in the fields of pharmaceuticals, nutrition, and cosmetics.

Mr. Otsuka joined the company in 1960. After holding various positions at Otsuka Group companies, he became the President of Otsuka Pharmaceutical Co. in 1976, and in 2008 was appointed the Chairman and CEO of Otsuka Holdings. 2008 was an important year for the relationship between France and the Otsuka Group, as this was the year that Otsuka Pharmaceutical acquired Nutrition et Santé and Alma.

The Otsuka Group has made considerable contributions to France's economy and has created many jobs in France. Thanks to Mr. Otsuka, the Otsuka Group has strengthened its French operations, and the Otsuka Group currently employs close to 2500 people in France and is among the leading Japanese investors in France.

Otsuka Pharmaceutical's French subsidiary, which markets human pharmaceuticals in France, had only 10 employees when it was founded in 2004, but it now employs eight times that many. In 2006, Otsuka's Abilify received the Prix Galien award, which is given for the development of a pharmaceutical product with groundbreaking therapeutic efficacy. Nutrition et Santé, which was acquired by Otsuka Pharmaceutical in this same year, manufactures functional and nutritional food products.

I would like to take this opportunity to once again praise the special relationship France has with the Otsuka Group, a relationship that has resulted in many past success stories, and one that I have no doubt will lead to many successes in the future as well.

Mr. Otsuka, you are a true friend of France. This is evident from the Otsuka Group’s enthusiasm for participating in events held by the French Embassy. Otsuka Group senior management has made every effort to forge solid, high-level relationships with French government officials, including the French Ambassador to Japan and officials at the Invest In France Agency.

Through the partnership the Otsuka Group has created with French industry, Mr. Otsuka has emphasized two things that the peoples of both of our countries have in common: finding value in work, and the enjoyment of life.

The government of France would like to express its gratitude for all the hard work of every Otsuka employee, for your actions as the head of the company, and for the contributions that you have made to foster the relationship between our two countries. Mr. Otsuka, on behalf of the President of France, I hereby award you the Officer Order of the Legion of Honor.

 

Nov 5, 2014

Read the full story with photos at:

https://www.otsuka.co.jp/en/company/globalnews/2014/1105_01.html

Otsuka Pharmaceutical's dry eye magazine advertising campaign was awarded the first-place prize in the "Tie-in Campaign – Cosmetics" category of the 57th Japan Magazine Advertising Association Award.

The theme of the campaign was “凸凹Eye” which means bumpy surfaced eyes. It focused on "The Eyes of Craftspeople," something for which Japan is renowned for, in order to make it easy to understand that the condition called dry eye is a disease that does not result simply in dry eyes, but caused by the mucosal abnormality on the surface of the eye and making it bumpy.

The campaign featured segments on the eyes of active female professionals, along with explanations from ophthalmologists, and ran in magazines with a predominantly middle-aged female readership, a group that is particularly prone to developing dry eye.

Otsuka executive Yoshiko Wakana of the Dermatologicals & Ophthalmologicals Sales Department attended the awards ceremony, which was held in Tokyo on November 5, 2014.

Otsuka Pharmaceutical conducted an educational campaign on dry eye in various media, including this magazine advertising campaign, internet sites, and television programs.

Ms. Wakana said, "I would like to help as many patients who are suffering from dry eye as possible, by providing them with both safe and effective medicines and with high-quality information."

Nov 1, 2014

Read the full story with photos at:

http://www.otsuka.co.jp/en/company/globalnews/detail.php?id=225&date=2016-02-01

Dr. Gregory Fox from Sydney, Australia was presented the Young Innovator in Tuberculosis Research Award sponsored by Otsuka during the 46th Union World Conference on Lung Health in Cape Town, South Africa in December 2015.

Dr. Fox is an Australian respiratory physician and recipient of the CJ Martin Fellowship from the Australian Government. His research focuses on TB case-finding and multidrug-resistant TB in high-burden settings. Dr. Fox was the foundation country director of the Woolcock Institute of Medical Research in Vietnam from 2009 to 2013. During that period, in partnership with the Vietnam National TB Program, he implemented a randomized controlled trial (the ACT2 study), screening over 25,000 people for TB.

The project was innovative in its use of randomized controlled trial methodology and electronic tools that were developed especially for the trial and are scalable. Additionally, the project demonstrated the feasibility of centrally coordinated tracing of everyone who has come in contact with a person diagnosed with TB. Currently, Dr. Fox is an investigator on several ongoing public health and clinical studies of TB screening and prevention in Vietnam. He also works as a respiratory physician at Royal Prince Alfred Hospital in Sydney, Australia.

Encouraging Young Researchers for the Continuation of Actions Against TB

The Young Innovator in TB Research Award was established through a global partnership between Otsuka Pharmaceutical and The Union. The award is administered by The Union with a grant provided by Otsuka. Award recipients are selected by a panel of experts organised independently by The Union.

The purpose of the award is to stimulate the advancement of innovative approaches in TB control and patient care. The award is open to young clinicians who have documented achievements in the formulation and implementation of clinical and operational research in the field of TB or multidrug-resistant TB.

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